Wang David S, Anderson David A, Fretz Peter C, Nguyen Thai T, Winfield Howard N
Department of Urology, Boston University School of Medicine, 720 Harrison Avenue, Boston, MA 02118, USA.
BJU Int. 2007 Mar;99(3):628-31. doi: 10.1111/j.1464-410X.2006.06662.x. Epub 2006 Dec 13.
To determine the feasibility of laparoscopic augmentation cystoplasty (LAC) in the porcine model and to compare LAC using standard bowel vs a small intestinal submucosa (SIS) allograft.
Fourteen female pigs underwent LAC; six had standard ileal AC and eight AC with SIS. All the pigs had limited cystometrogram studies before surgery to determine bladder capacity. At 6 weeks after surgery the pigs were anaesthetized, the bladder capacities were re-assessed and then the pigs were killed; the bladders were harvested and examined histologically.
In all, 12 of 14 pigs completed the 6-week survival period; two pigs from the SIS group died from urinary ascites secondary to anastomotic leaks at the cystoplasty site. There were no complications in the ileal augmentation group. The operative duration was similar in both groups. The bladder capacities increased significantly in both groups, although more reliably in the native ileum group. In two pigs in the SIS group there was no increase in bladder capacity.
LAC is feasible in the porcine model and results in a significant increase in bladder capacity. AC using SIS does not appear to increase bladder capacity as reliably as native ileum, and has a higher complication rate.
确定腹腔镜下膀胱扩大成形术（LAC）在猪模型中的可行性，并比较使用标准肠段与小肠黏膜下层（SIS）同种异体移植物进行LAC的效果。
14只雌性猪接受了LAC；6只进行标准回肠膀胱扩大术，8只使用SIS进行膀胱扩大术。所有猪在手术前均进行了有限的膀胱测压研究以确定膀胱容量。术后6周，对猪实施麻醉，重新评估膀胱容量，然后处死猪；取出膀胱并进行组织学检查。
14只猪中共有12只完成了6周的生存期；SIS组有2只猪因膀胱扩大成形术部位吻合口漏继发尿腹水而死亡。回肠扩大组无并发症。两组手术时间相似。两组膀胱容量均显著增加，尽管在自体回肠组增加得更可靠。SIS组有2只猪膀胱容量未增加。
LAC在猪模型中是可行的，并且可使膀胱容量显著增加。使用SIS进行膀胱扩大术似乎不像自体回肠那样可靠地增加膀胱容量，且并发症发生率更高。
