Beglinger Leigh J, Duff Kevin, Van Der Heiden Sara, Moser David J, Bayless John D, Paulsen Jane S, Gingrich Roger
Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242-1000, USA.
J Int Neuropsychol Soc. 2007 Jan;13(1):172-7. doi: 10.1017/S1355617707070208.
The current study characterizes cognitive and psychiatric status in hematopoietic stem cell transplantation (HSCT) patients shortly before and after transplant. Thirty adult patients were assessed prospectively 1-2 weeks before transplantation and 100 days posttransplantation on neuropsychological and psychiatric measures. Before transplant, participants showed mild impairments on several neuropsychological measures, with the poorest performances occurring on learning and attention. Psychiatric functioning was significantly elevated compared with normative data. Significant improvements, however, were observed on neuropsychological measures by 100 days after transplant. Depression and anxiety scores also improved. Candidates for HSCT experienced mild diffuse cognitive dysfunction and psychiatric morbidity before the procedure, but these symptoms significantly improved by 3 months following their transplant in this small sample. Education about these possible pretransplant sequelae and the potential for rebound may be helpful to patients and families as they prepare for this treatment and the recovery period.
当前研究对造血干细胞移植（HSCT）患者在移植前后不久的认知和精神状态进行了特征描述。30名成年患者在移植前1 - 2周和移植后100天接受了神经心理学和精神方面的前瞻性评估。移植前，参与者在多项神经心理学测试中表现出轻度损伤，在学习和注意力方面表现最差。与标准数据相比，精神功能显著升高。然而，移植后100天，神经心理学测试结果有显著改善。抑郁和焦虑评分也有所改善。在这个小样本中，HSCT候选患者在手术前经历了轻度弥漫性认知功能障碍和精神疾病，但这些症状在移植后3个月时显著改善。在患者及其家人为这种治疗和恢复期做准备时，告知他们这些可能的移植前后遗症以及症状反弹的可能性或许会有所帮助。
