Ennezat P V, Marechaux S, Asseman P, Lejemtel T H, Van Belle E, Bauters C, De Groote P
Cardiology Hospital, Lille, France.
Minerva Cardioangiol. 2006 Dec;54(6):725-33.
Functional mitral regurgitation (MR) frequently develops during the progression of chronic heart failure and predicts poor outcome. Impaired left ventricular (LV) function, LV remodeling associated with papillary muscle apical displacement and annular enlargement result in decreased mitral closing forces and tenting of the mitral valve at closure. Reduced closing forces and tenting both promote MR. Active myocardial ischemia, myocardial asynchronism and excessive loading conditions worsen MR at rest and during exercise. The therapeutic target in functional MR is the left ventricle and not the valve.
功能性二尖瓣反流（MR）在慢性心力衰竭进展过程中经常出现，并预示着不良预后。左心室（LV）功能受损、与乳头肌心尖移位和瓣环扩大相关的LV重塑导致二尖瓣关闭力降低以及二尖瓣在关闭时呈帐篷样改变。关闭力降低和呈帐篷样改变均会促进MR。活动性心肌缺血、心肌不同步和负荷过重情况会使静息和运动时的MR恶化。功能性MR的治疗靶点是左心室而非瓣膜。
