Després Jean-Pierre, Lemieux Isabelle
Québec Heart Institute, Hôpital Laval Research Centre, 2725 chemin Sainte-Foy, Pavilion Marguerite-D'Youville, 4th Floor, Quebec City, QC G1V 4G5, Canada.
Nature. 2006 Dec 14;444(7121):881-7. doi: 10.1038/nature05488.
Metabolic syndrome is associated with abdominal obesity, blood lipid disorders, inflammation, insulin resistance or full-blown diabetes, and increased risk of developing cardiovascular disease. Proposed criteria for identifying patients with metabolic syndrome have contributed greatly to preventive medicine, but the value of metabolic syndrome as a scientific concept remains controversial. The presence of metabolic syndrome alone cannot predict global cardiovascular disease risk. But abdominal obesity - the most prevalent manifestation of metabolic syndrome - is a marker of 'dysfunctional adipose tissue', and is of central importance in clinical diagnosis. Better risk assessment algorithms are needed to quantify diabetes and cardiovascular disease risk on a global scale.
代谢综合征与腹部肥胖、血脂紊乱、炎症、胰岛素抵抗或全面发展的糖尿病以及心血管疾病发生风险增加相关。用于识别代谢综合征患者的既定标准对预防医学有很大贡献，但代谢综合征作为一个科学概念的价值仍存在争议。仅代谢综合征的存在并不能预测整体心血管疾病风险。但是腹部肥胖——代谢综合征最常见的表现——是“功能失调的脂肪组织”的一个标志，并且在临床诊断中至关重要。需要更好的风险评估算法来在全球范围内量化糖尿病和心血管疾病风险。
