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克服因先前接触野生型病毒而导致的对疟疾重组痘苗病毒抗体反应的抑制。

Overcoming inhibition of antibody responses to a malaria recombinant vaccinia virus caused by prior exposure to wild type virus.

作者信息

Etlinger H M, Altenburger W

机构信息

Central Research Units, F. Hoffman-La Roche Ltd., Basel, Switzerland.

出版信息

Vaccine. 1991 Jul;9(7):470-2. doi: 10.1016/0264-410x(91)90030-a.

DOI:10.1016/0264-410x(91)90030-a
PMID:1716807
Abstract

Pre-injection of mice with vaccinia virus inhibited the subsequent antibody response to a recombinant polypeptide expressed by vaccinia virus. The inhibition was overcome following additional challenges with recombinant vaccinia virus. This suggests that a potential disadvantage in vaccinia-immune individuals can be circumvented and may be outweighed by the advantages of the vector.

摘要

预先给小鼠注射痘苗病毒会抑制其随后对痘苗病毒表达的重组多肽的抗体反应。在用重组痘苗病毒再次攻击后，这种抑制作用被克服。这表明痘苗免疫个体中存在的潜在劣势可以被规避，而且载体的优势可能超过这些劣势。

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