Ersin Nazan Kocataş, Gülen Figen, Eronat Nesrin, Cogulu Dilsah, Demir Esen, Tanaç Remziye, Aydemir Söhret
Department of Pedodontics, Ege University, Bornova-Izmir, Turkey.
Pediatr Int. 2006 Dec;48(6):549-54. doi: 10.1111/j.1442-200X.2006.02281.x.
The aim of this study was to investigate the caries risk of asthmatics in relation to dental plaque indices, salivary flow rate, pH and buffer capacity, saliva composition and salivary levels of Streptococcus mutans compared with healthy subjects and also to evaluate these parameters within different groups of asthmatics according to their medication, duration and severity of the disease.
The study group composed of 106 asthmatics and 100 healthy controls with the same age and social background aged between 6 and 19-years-old. For dental examinations, World Health Organization criteria and for plaque indices the Silness and Löe plaque index was used. All data were analyzed using t-test, chi2-test, Spearman rank correlation, Kruskal- Wallis, Mann-Whitney U-tests and Logistic Regression Analysis with Forward Stepwise Likelihood ratio method.
A statistically significant decrease in the salivary flow rate and pH were found in the asthmatic group. The children in the asthmatic group aged between 6 and 10 years had significantly higher caries prevalence compared with the control group at the same age. There was a negative correlation between the duration of medication and the salivary pH and a positive correlation between duration of illness and the salivary levels of S. mutans in the asthmatics.
It was found that asthma, through its disease status and its pharmacotherapy, carries some risk factors including decreased salivary flow rate and pH for caries development. It was also demonstrated that the duration of medication and illness had significant influences on the risk of caries in asthmatics.
本研究旨在调查哮喘患者与健康受试者相比，在牙菌斑指数、唾液流速、pH值和缓冲能力、唾液成分以及变形链球菌唾液水平方面的龋齿风险，并根据哮喘患者的用药情况、病程和疾病严重程度，评估不同哮喘患者组中的这些参数。
研究组由106名6至19岁、年龄和社会背景相同的哮喘患者和100名健康对照组成。牙科检查采用世界卫生组织标准，牙菌斑指数采用Silness和Löe菌斑指数。所有数据采用t检验、卡方检验、Spearman等级相关性分析、Kruskal-Wallis检验、Mann-Whitney U检验以及向前逐步似然比法进行逻辑回归分析。
哮喘组的唾液流速和pH值在统计学上显著降低。哮喘组中6至10岁的儿童与同龄对照组相比，龋齿患病率显著更高。哮喘患者的用药时间与唾液pH值呈负相关，病程与变形链球菌唾液水平呈正相关。
研究发现，哮喘通过其疾病状态和药物治疗，存在一些导致龋齿发生的风险因素，包括唾液流速降低和pH值降低。还表明用药时间和病程对哮喘患者的龋齿风险有显著影响。
