Ashuja R B, Nandini D B, Vidyasagar B, Ashwini R, Donoghue Mandana, Madhushankari G S
Independent Researcher, Davangere, Karnataka, India.
Department of Oral Pathology, Dental College, Regional Institute of Medical Sciences, Imphal, Manipur, India.
J Oral Maxillofac Pathol. 2018 Jan-Apr;22(1):144. doi: 10.4103/jomfp.JOMFP_235_15.
Antiasthmatic medications such as β2 agonists and corticosteroids have shown potential side effects such as increased caries risk and oral candidiasis. Studies evaluating microbial changes in adult asthmatics are very scanty in the literature. The present study aimed to evaluate the effects of asthma and its medication on cariogenic bacteria and in adult asthmatics.
Our aim was to evaluate and compare counts of (SM) and lactobacilli in plaque and in saliva samples of adult asthmatics with controls and during the course of medication longitudinally.
Samples were collected from twenty recently diagnosed asthmatic adults and twenty controls for estimation of microbial counts at baseline and at 3 and 6 month after initiation of medication among cases.
Asthmatics at baseline had higher microbial counts than controls, but the difference was not statistically significant. Comparison between asthmatics at baseline and 3 month after initiation of medication showed an increase in counts of SM, lactobacilli and decreased counts though the difference was not significant. Comparison between asthmatics at baseline and 6 month and also between 3 and 6 month showed significantly increased counts of SM. Although there was an increase in counts of lactobacilli and decreased counts, significant results were not noted. Asthmatics showed increased microbial counts than controls overall.
Asthmatics were found to have higher microbial counts than controls at baseline. Increase in SM and lactobacilli counts in asthmatics after medication emphasizes the need to monitor these patients regularly.
β2 激动剂和皮质类固醇等抗哮喘药物已显示出潜在的副作用，如龋齿风险增加和口腔念珠菌病。在文献中，评估成年哮喘患者微生物变化的研究非常稀少。本研究旨在评估哮喘及其药物治疗对成年哮喘患者致龋菌的影响。
我们的目的是纵向评估和比较成年哮喘患者与对照组在用药过程中菌斑和唾液样本中变形链球菌（SM）和乳酸杆菌的数量。
从 20 名新诊断的成年哮喘患者和 20 名对照中采集样本，以估计基线时以及病例组用药后 3 个月和 6 个月时的微生物数量。
基线时哮喘患者的微生物数量高于对照组，但差异无统计学意义。基线时哮喘患者与用药后 3 个月的哮喘患者相比，SM、乳酸杆菌数量增加，而变形链球菌数量减少，尽管差异不显著。基线时哮喘患者与 6 个月时以及 3 个月与 6 个月时的哮喘患者相比，SM 数量显著增加。尽管乳酸杆菌数量增加，变形链球菌数量减少，但未观察到显著结果。总体而言，哮喘患者的微生物数量高于对照组。
发现哮喘患者在基线时的微生物数量高于对照组。用药后哮喘患者中 SM 和乳酸杆菌数量的增加强调了对这些患者进行定期监测的必要性。
