Adams Mark R
Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia.
Endothelium. 2006 Nov-Dec;13(6):367-74. doi: 10.1080/10623320601061573.
The endothelium is crucial in the maintenance of normal vascular function and disturbance of this balance is a key early event in the development of vascular disease. A wide range of techniques currently exists for assessment of endothelial function in both the coronary and the peripheral vasculature. Many of these in vivo tests have concentrated on measuring nitric oxide bioavailability, however more recently methods for measuring other vascular parameters, such as tissue-plasminogen activator release, have been used. Furthermore indirect systemic measurements of endothelial function and endothelial progenitor cells have been investigated. These methods have given great insights into the pathophysiology of atherosclerosis and have aided in the development of a number of antiatherosclerotic therapies. Importantly the methods used to date for assessing endothelial function in vivo are accurate, reproducible and correlate with the future risk of cardiovascular events. The development of new techniques and the constant refinement of established techniques suggest that many more insights are to be gained from clinical assessment of endothelial function.
内皮对于维持正常血管功能至关重要，而这种平衡的紊乱是血管疾病发展过程中的一个关键早期事件。目前有多种技术可用于评估冠状动脉和外周血管系统中的内皮功能。这些体内测试中的许多都集中在测量一氧化氮生物利用度上，然而最近也使用了测量其他血管参数的方法，例如组织纤溶酶原激活物释放。此外，还研究了内皮功能和内皮祖细胞的间接全身测量方法。这些方法为动脉粥样硬化的病理生理学提供了深刻见解，并有助于开发多种抗动脉粥样硬化疗法。重要的是，迄今为止用于体内评估内皮功能的方法准确、可重复，并且与未来心血管事件的风险相关。新技术的发展以及现有技术的不断完善表明，从内皮功能的临床评估中还将获得更多见解。
