内皮素拮抗剂治疗心力衰竭的临床试验：发表成果有益于公众健康。
Clinical trials of endothelin antagonists in heart failure: publication is good for the public health.
作者信息
Kelland N F, Webb D J
出版信息
Heart. 2007 Jan;93(1):2-4. doi: 10.1136/hrt.2006.089250.
Abstract
The failure of endothelin antagonists to show benefit in heart failure cannot be understood until all the clinical trials are fully published.
摘要
在内皮素拮抗剂在心力衰竭中未能显示出益处的原因得到理解之前，所有临床试验都必须完全发表。
相似文献
1
Clinical trials of endothelin antagonists in heart failure: publication is good for the public health.内皮素拮抗剂治疗心力衰竭的临床试验：发表成果有益于公众健康。
Heart. 2007 Jan;93(1):2-4. doi: 10.1136/hrt.2006.089250.
2
Clinical trials of endothelin antagonists in heart failure: a question of dose?内皮素拮抗剂用于心力衰竭的临床试验：剂量问题？
Exp Biol Med (Maywood). 2006 Jun;231(6):696-9.
3
Endothelin receptor selectivity in chronic kidney disease: rationale and review of recent evidence.慢性肾脏病中内皮素受体的选择性：理论依据及近期证据综述
Eur J Clin Invest. 2009 Jun;39 Suppl 2:50-67. doi: 10.1111/j.1365-2362.2009.02121.x.
4
Endothelin expression and the progression of heart failure: exemplifying the vagaries of therapeutic development.内皮素表达与心力衰竭的进展：治疗发展变幻莫测的例证
Circulation. 2004 Jan 20;109(2):143-5. doi: 10.1161/01.CIR.0000110644.92116.91.
5
[Endothelin-1 receptor antagonists in heart failure].
Arch Mal Coeur Vaiss. 2003 Oct;96(10):984-7.
6
Current status of endothelin blockade for the treatment of cardiovascular and pulmonary vascular disease.内皮素阻断剂治疗心血管和肺血管疾病的现状
Curr Opin Investig Drugs. 2003 Mar;4(3):298-302.
7
Endothelin receptor antagonism in pulmonary arterial hypertension--a role for selective ET(A) inhibition?内皮素受体拮抗剂在肺动脉高压中的作用——选择性ET(A)抑制的作用？
Curr Med Res Opin. 2006 Dec;22(12):2567-74. doi: 10.1185/030079906X158020.
8
Are angiotensin II receptor antagonists indicated in chronic heart failure?血管紧张素 II 受体拮抗剂是否适用于慢性心力衰竭？
Heart Fail Monit. 2002;2(3):85-7.
9
Endothelin receptor antagonists.内皮素受体拮抗剂
Pharmacol Ther. 2006 Jun;110(3):386-414. doi: 10.1016/j.pharmthera.2005.08.012. Epub 2005 Oct 10.
10
[Endothelin and heart failure].
Nihon Rinsho. 2004 Sep;62 Suppl 9:648-54.
引用本文的文献
1
The Role of Endothelin-1, Kidney Function and Diabetes in Patients With Coronary Artery Disease Underwent Percutaneous Coronary Intervention.内皮素-1、肾功能和糖尿病在接受经皮冠状动脉介入治疗的冠心病患者中的作用
J Diabetes. 2025 Jul;17(7):e70127. doi: 10.1111/1753-0407.70127.
2
Current and future strategies for targeting the endothelin pathway in cardiovascular disease.当前和未来针对心血管疾病内皮素途径的靶向策略。
Nat Cardiovasc Res. 2023 Nov;2(11):972-990. doi: 10.1038/s44161-023-00347-2. Epub 2023 Nov 2.
3
Signaling cascades in the failing heart and emerging therapeutic strategies.衰竭心脏中的信号级联反应和新兴治疗策略。
Signal Transduct Target Ther. 2022 Apr 23;7(1):134. doi: 10.1038/s41392-022-00972-6.
4
Kidney involvement in systemic sclerosis: From pathogenesis to treatment.系统性硬化症中的肾脏受累：从发病机制到治疗
J Scleroderma Relat Disord. 2018 Feb;3(1):43-52. doi: 10.1177/2397198318758607. Epub 2018 Apr 4.
5
Structural heart defects associated with ET mutation, a cause of Hirschsprung disease.与 ET 突变相关的结构性心脏缺陷，是先天性巨结肠症的一个病因。
BMC Cardiovasc Disord. 2021 Oct 2;21(1):475. doi: 10.1186/s12872-021-02281-2.
6
Endothelin-1 axes in the framework of predictive, preventive and personalised (3P) medicine.预测、预防和个性化（3P）医学框架下的内皮素-1轴
EPMA J. 2021 Aug 4;12(3):265-305. doi: 10.1007/s13167-021-00248-z. eCollection 2021 Sep.
7
Endothelins in cardiovascular biology and therapeutics.内皮素在心血管生物学和治疗学中的作用。
Nat Rev Cardiol. 2019 Aug;16(8):491-502. doi: 10.1038/s41569-019-0176-3.
8
The Role of G Protein-Coupled Receptors in the Right Ventricle in Pulmonary Hypertension.G蛋白偶联受体在肺动脉高压右心室中的作用
Front Cardiovasc Med. 2018 Dec 17;5:179. doi: 10.3389/fcvm.2018.00179. eCollection 2018.
9
Neurohormonal Blockade in Heart Failure.心力衰竭中的神经激素阻断
Card Fail Rev. 2017 Apr;3(1):19-24. doi: 10.15420/cfr.2016:22:2.
10
Modulation of endothelin receptors in the failing right ventricle of the heart and vasculature of the lung in human pulmonary arterial hypertension.人肺动脉高压时衰竭右心室及肺血管中内皮素受体的调节
Life Sci. 2014 Nov 24;118(2):391-6. doi: 10.1016/j.lfs.2014.02.020. Epub 2014 Feb 26.
本文引用的文献
1
Trial registration report card.试验注册报告卡。
N Engl J Med. 2005 Dec 29;353(26):2809-11. doi: 10.1056/NEJMe058279.
2
Direct comparison of selective endothelin A and non-selective endothelin A/B receptor blockade in chronic heart failure.慢性心力衰竭中选择性内皮素A受体与非选择性内皮素A/B受体阻断的直接比较。
Heart. 2005 Jul;91(7):914-9. doi: 10.1136/hrt.2004.040386.
3
Specific inhibition of the endothelin A receptor with ZD4054: clinical and pre-clinical evidence.使用ZD4054对内皮素A受体进行特异性抑制：临床及临床前证据
Br J Cancer. 2005 Jun 20;92(12):2148-52. doi: 10.1038/sj.bjc.6602676.
4
Endothelin antagonism in pulmonary hypertension, heart failure, and beyond.内皮素拮抗作用在肺动脉高压、心力衰竭及其他病症中的应用
Heart. 2005 Jun;91(6):825-31. doi: 10.1136/hrt.2004.053991.
5
Principles for international registration of protocol information and results from human trials of health related interventions: Ottawa statement (part 1).健康相关干预措施人体试验方案信息及结果的国际注册原则：渥太华声明（第1部分）
BMJ. 2005 Apr 23;330(7497):956-8. doi: 10.1136/bmj.330.7497.956.
6
Endothelial function: cardiac events.内皮功能：心脏事件
Circulation. 2005 Jan 25;111(3):363-8. doi: 10.1161/01.CIR.0000153339.27064.14.
7
Comparison of selective ET(A) and ET(B) receptor antagonists in patients with chronic heart failure.慢性心力衰竭患者中选择性内皮素A（ET(A)）和内皮素B（ET(B)）受体拮抗剂的比较。
Eur J Heart Fail. 2005 Jan;7(1):37-42. doi: 10.1016/j.ejheart.2004.08.001.
8
Endothelin A receptor antagonism and angiotensin-converting enzyme inhibition are synergistic via an endothelin B receptor-mediated and nitric oxide-dependent mechanism.内皮素A受体拮抗作用与血管紧张素转换酶抑制作用通过内皮素B受体介导和一氧化氮依赖机制产生协同作用。
J Am Soc Nephrol. 2004 Oct;15(10):2601-10. doi: 10.1097/01.ASN.0000141313.84470.4B.
9
Clinical trial registration: a statement from the International Committee of Medical Journal Editors.临床试验注册：国际医学期刊编辑委员会声明
Lancet. 2004;364(9438):911-2. doi: 10.1016/S0140-6736(04)17034-7.
10
Long-term effects of darusentan on left-ventricular remodelling and clinical outcomes in the EndothelinA Receptor Antagonist Trial in Heart Failure (EARTH): randomised, double-blind, placebo-controlled trial.内皮素A受体拮抗剂治疗心力衰竭试验（EARTH）中达卢生坦对左心室重构及临床结局的长期影响：随机、双盲、安慰剂对照试验
Lancet. 2004;364(9431):347-54. doi: 10.1016/S0140-6736(04)16723-8.
Zotero 插件