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[慢性心力衰竭的对症治疗的主要方面]

[The main aspects of symptomatic therapy of chronic heart failure].

作者信息

Zaliaduonyte-Peksiene Diana, Mikuckaite Lina, Kavoliūniene Ausra

机构信息

Department of Cardiology, Kaunas University of Medicine, Eiveniu 2, 50009 Kaunas, Lithuania.

出版信息

Medicina (Kaunas). 2006;42(11):949-55.

Abstract

The main aims of the treatment of chronic heart failure are to improve and to maintain the quality of life, to increase duration of life, to decrease mortality, to prevent diseases leading to the heart failure development, and to prevent the progression of heart failure. Diuretics are the drugs of first choice for the treatment of congestive heart failure. They can improve the quality of patient's life quite quickly. Noncompliance to methodological diuretic use can cause a serious damage such as metabolic disorders, arrhythmias, and even sudden death. Loop diuretics are the drugs of choice. Resistance to diuretics occurs in 10-20% of the cases during the course of treatment; therefore, drug combination as well as dose modification is required. Diuretics are not recommended to use alone for a symptomatic relief. They are prescribed in combination with beta-blockers, angiotensin-converting-enzyme inhibitors, and/or angiotensin receptor blockers for a continuous pathogenetic therapy of congestive heart failure. Digoxin in combination with diuretics is the drug of choice for treatment of heart failure when tachyarrhythmia or severe systolic left ventricular dysfunction appears or it is impossible to administer beta-blockers. In this article, the guidelines of European Society of Cardiology and also American College of Cardiology and American Heart Association for the symptomatic management of congestive heart failure, updated in 2005, are reviewed.

摘要

慢性心力衰竭治疗的主要目标是改善并维持生活质量、延长寿命、降低死亡率、预防导致心力衰竭发生的疾病以及防止心力衰竭进展。利尿剂是治疗充血性心力衰竭的首选药物。它们能较快改善患者生活质量。不按照方法使用利尿剂会造成严重损害,如代谢紊乱、心律失常甚至猝死。袢利尿剂是首选药物。治疗过程中10% - 20%的病例会出现利尿剂抵抗;因此,需要联合用药及调整剂量。不建议单独使用利尿剂来缓解症状。它们与β受体阻滞剂、血管紧张素转换酶抑制剂和/或血管紧张素受体阻滞剂联合使用,用于充血性心力衰竭的持续病因治疗。当出现快速心律失常或严重收缩期左心室功能障碍或无法使用β受体阻滞剂时,地高辛与利尿剂联合是治疗心力衰竭的首选药物。本文回顾了欧洲心脏病学会以及美国心脏病学会和美国心脏协会于2005年更新的充血性心力衰竭症状管理指南。

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