Haider Masoom A, Sitartchouk Igor, Roberts Timothy P L, Fyles Anthony, Hashmi Ali T, Milosevic Michael
Department of Medical Imaging, University Health Network and Mount Sinai Hospital, University of Toronto, Ontario, Canada.
J Magn Reson Imaging. 2007 Jan;25(1):153-9. doi: 10.1002/jmri.20795.
To correlate permeability (rk(trans)), extracellular volume fraction (rv(e)), relative to muscle and initial area under the enhancement curve (IAUC(60m)) determined by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with in vivo measurements of interstitial fluid pressure (IFP) in patients with cervical cancer.
DCE-MRI and IFP measurements were performed of cervical tumors of 32 patients prior to therapy. Median tumor rk(trans) and rv(e) were derived from a bidirectional two-compartment model using an input function derived from muscle. Median IAUC(60m) was defined as the integral of tumor enhancement in the first 60 seconds divided by the similar muscle enhancement integral. These parameters were correlated with the mean tumor IFP.
There was a significant negative correlation between IAUC(60m) and IFP (r = -0.42, P = 0.016) and between rk(trans) and IFP (r = -0.47, P = 0.008). The was no significant correlation between IFP and rv(e).
There is a moderate negative correlation between IAUC(60m), rk(trans), and IFP in cervical cancer. This suggests that these parameters may be of value in assessment of tumor behavior.
通过动态对比增强磁共振成像（DCE-MRI）测定宫颈癌患者的通透性（rk(trans)）、细胞外体积分数（rv(e)）（相对于肌肉）以及增强曲线下初始面积（IAUC(60m)），并将其与体内间质液压力（IFP）测量值进行关联。
对32例患者治疗前的宫颈肿瘤进行DCE-MRI和IFP测量。肿瘤rk(trans)和rv(e)的中位数来自双向双室模型，使用从肌肉得出的输入函数。IAUC(60m)中位数定义为肿瘤在最初60秒内增强的积分除以相似肌肉增强积分。这些参数与平均肿瘤IFP进行关联。
IAUC(60m)与IFP之间存在显著负相关（r = -0.42，P = 0.016），rk(trans)与IFP之间也存在显著负相关（r = -0.47，P = 0.008）。IFP与rv(e)之间无显著相关性。
宫颈癌中IAUC(60m)、rk(trans)与IFP之间存在中度负相关。这表明这些参数在评估肿瘤行为方面可能具有价值。
