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兔巨核细胞和血小板对血管活性神经肽摄取的放射自显影分析。

Autoradiographic analysis of vasoactive neuropeptide uptake by rabbit megakaryocytes and platelets.

作者信息

Daimon T

机构信息

Department of Anatomy, School of Medicine, Teikyo University, Tokyo, Japan.

出版信息

J Anat. 1991 Jun;176:105-12.

PMID:1717418
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1260318/
Abstract

Autoradiographic analysis has been performed to determine whether or not platelets and megakaryocytes can take up in vitro vasoactive neuropeptides such as [3H]angiotensin II, [3H]neuropeptide Y, [3H]substance P and [3H]vasopressin. Light microscope autoradiography has revealed the active uptake of [3H]angiotensin II by megakaryocytes. [3H]angiotensin II uptake by platelets has also been confirmed by electron microscope autoradiography. Silver grains are preferentially associated with the dense bodies of platelets. Neither megakaryocytes nor platelets show any active uptake of [3H]neuropeptide Y or [3H]substance P. Megakaryocytes are slightly labelled after incubation with [3H]vasopressin.

摘要

已进行放射自显影分析，以确定血小板和巨核细胞是否能够在体外摄取血管活性神经肽，如[3H]血管紧张素II、[3H]神经肽Y、[3H]P物质和[3H]加压素。光学显微镜放射自显影显示巨核细胞对[3H]血管紧张素II有主动摄取。电子显微镜放射自显影也证实了血小板对[3H]血管紧张素II的摄取。银颗粒优先与血小板的致密体相关。巨核细胞和血小板均未显示对[3H]神经肽Y或[3H]P物质有任何主动摄取。巨核细胞在与[3H]加压素孵育后有轻微标记。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf5b/1260318/39f0da71f5d9/janat00156-0114-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf5b/1260318/e384aa816a96/janat00156-0111-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf5b/1260318/7de41a6d4b24/janat00156-0112-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf5b/1260318/39f0da71f5d9/janat00156-0114-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf5b/1260318/e384aa816a96/janat00156-0111-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf5b/1260318/7de41a6d4b24/janat00156-0112-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf5b/1260318/39f0da71f5d9/janat00156-0114-a.jpg

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本文引用的文献

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The effects of glutaraldehyde and formaldehyde fixation on the retention and subcellular location of [3H]5-hydroxytryptamine in rabbit platelets: a study using liquid scintillation counting and E.M. autoradiography.戊二醛和甲醛固定对兔血小板中[3H]5-羟色胺的保留及亚细胞定位的影响：一项使用液体闪烁计数法和电子显微镜放射自显影术的研究
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Receptors for angiotensin II on platelets from man.人类血小板上的血管紧张素II受体。
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Chemical anatomy of the brain.大脑的化学解剖学
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