一种通过微流控纸基定量化学分析（MSPQC）检测大肠杆菌对氨苄西林药敏性的新方法。
A new antimicrobial susceptibility testing method of Escherichia coli against ampicillin by MSPQC.
作者信息
He Fengjiao, Zhou Juan
机构信息
College of Chemistry and Chemical Engineering, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, 410082, China.
出版信息
J Microbiol Methods. 2007 Mar;68(3):563-7. doi: 10.1016/j.mimet.2006.10.013. Epub 2006 Dec 18.
A new antimicrobial susceptibility testing method by multi-channel series piezoelectric quartz crystal (MSPQC) was proposed. This method was used to test susceptibility of clinical Escherichia coli isolates against ampicillin. Both the minimum inhibitory concentrations (MICs) and interpretive categorization of clinical E. coli isolates were determined by proposed method. Comparing tests were run at the same time by the agar dilution method and the disk diffusion method. The experimental results showed that MSPQC method had a good agreement with the reference methods. Compared with those methods, the MSPQC method is simple, rapid, and convenient to perform. It can offer both a minimum inhibitory concentration (MIC) and an interpretive category result.
提出了一种基于多通道串联压电石英晶体（MSPQC）的新型抗菌药敏试验方法。该方法用于检测临床分离的大肠杆菌对氨苄西林的敏感性。通过该方法确定了临床大肠杆菌分离株的最低抑菌浓度（MIC）和解释分类。同时采用琼脂稀释法和纸片扩散法进行对比试验。实验结果表明，MSPQC方法与参考方法具有良好的一致性。与这些方法相比，MSPQC方法操作简单、快速、方便。它既能提供最低抑菌浓度（MIC），又能给出解释分类结果。
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