He C, Zhao Y, Chen H D
Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang.
J Dermatol. 1991 Apr;18(4):196-200. doi: 10.1111/j.1346-8138.1991.tb03067.x.
Employing an avidin-biotin complex immunoperoxidase technique, it was found that there was OKM5 but no OKM1 antigen expression on the keratinocytes of the upper epidermis from all the studied specimens of seborrheic keratosis, verrucous nevus, Bowen's disease, BCC, SCC, MM, lichen planus, psoriasis vulgaris, condyloma acuminatum, and sporotrichosis as well as in two of eight cases of nevus pigmentosus. Our findings indicate that OKM5 antigen expression on epidermal keratinocytes is usually associated with dermal infiltration. It is assumed that human keratinocytes in cutaneous lesions, like the OKM1- OKM5+ monocyte/macrophage lineages, might play certain roles in immune responses and possibly function as antigen-presenting cells.
采用抗生物素蛋白-生物素复合物免疫过氧化物酶技术发现，在脂溢性角化病、疣状痣、鲍恩病、基底细胞癌、鳞状细胞癌、恶性黑素瘤、扁平苔藓、寻常型银屑病、尖锐湿疣、孢子丝菌病的所有研究标本以及八例色素痣中的两例中，上表皮角质形成细胞存在OKM5抗原表达，但无OKM1抗原表达。我们的研究结果表明，表皮角质形成细胞上的OKM5抗原表达通常与真皮浸润有关。据推测，皮肤病变中的人类角质形成细胞，如OKM1-OKM5 +单核细胞/巨噬细胞谱系，可能在免疫反应中发挥某些作用，并可能作为抗原呈递细胞发挥功能。
