瞬时受体电位通道、天然免疫反应中的钙和氧化还原传感器
TRPM channels, calcium and redox sensors during innate immune responses.
作者信息
Massullo Pam, Sumoza-Toledo Adriana, Bhagat Harivadan, Partida-Sánchez Santiago
机构信息
Columbus Children's Research Institute, Center for Microbial Pathogenesis, The Ohio State University, Columbus, OH 43205, USA.
出版信息
Semin Cell Dev Biol. 2006 Dec;17(6):654-66. doi: 10.1016/j.semcdb.2006.11.006. Epub 2006 Nov 21.
Melastatin-related TRPM ion channels have emerged as novel therapeutic targets due to their potential ability to modulate the function and fate of immune cells during inflammation, innate, and adaptive immunity. Four family members, TRPM1, TRPM2, TRPM4 and TRPM7 have a strong presence in the immune system. TRPM channels regulate ion-homeostasis by sensing cellular redox status and cytoplasmic calcium levels. TRPM2 for example, is highly expressed in phagocytes. This channel is activated by intracellular ADP-ribose upon exposure to oxidative stress and induces cell death. Here we will review the functional links between TRPM-mediated ion conductance, chemotaxis, apoptosis, and innate immunity.
与褪黑素相关的瞬时受体电位M型（TRPM）离子通道已成为新型治疗靶点，因为它们在炎症、先天性免疫和适应性免疫过程中具有调节免疫细胞功能和命运的潜在能力。四个家族成员，即TRPM1、TRPM2、TRPM4和TRPM7在免疫系统中大量存在。TRPM通道通过感知细胞氧化还原状态和细胞质钙水平来调节离子稳态。例如，TRPM2在吞噬细胞中高度表达。该通道在暴露于氧化应激时被细胞内二磷酸腺苷核糖激活，并诱导细胞死亡。在此，我们将综述TRPM介导的离子传导、趋化性、细胞凋亡和先天性免疫之间的功能联系。
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