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The 40-kilodalton to autoantigen associates with nucleotides 21 to 64 of human mitochondrial RNA processing/7-2 RNA in vitro.

作者信息

Yuan Y, Tan E, Reddy R

机构信息

Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030.

出版信息

Mol Cell Biol. 1991 Oct;11(10):5266-74. doi: 10.1128/mcb.11.10.5266-5274.1991.

DOI:10.1128/mcb.11.10.5266-5274.1991
PMID:1717826
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC361579/
Abstract

A 40-kDa To antigen recognized by sera from some patients with autoimmune diseases is an integral component of both human RNase P and mitochondrial RNA processing (MRP) RNase. Human MRP and RNase P RNAs, synthesized in vitro, readily associate with the To antigen present in the HeLa cell extract. Using this in vitro reconstitution system, the binding site of the To antigen is localized to a 44-nucleotide-long sequence corresponding to nucleotides 21 to 64 of the human MRP RNA. UV cross-linking experiments showed that the To antigen binds directly to MRP RNA and to RNase P (H1) RNA through RNA-protein interactions. Although the MRP RNA and RNAse P (H1) RNA show sequence homology in four conserved blocks (H. A. Gold, J. N. Topper, D. A. Clayton, and J. Craft, Science 245:1377-1380, 1989), the To antigen-binding site in MRP RNA does not show any obvious primary sequence homology with H1 RNA. These data suggest that the To antigen binds to a conserved and presumably a common secondary or tertiary structure in human MRP and RNase P RNAs.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1025/361579/e26e58fa2b57/molcellb00034-0478-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1025/361579/4c984dc162d1/molcellb00034-0474-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1025/361579/8faeb96f3f8b/molcellb00034-0474-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1025/361579/4a66b209f7c0/molcellb00034-0475-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1025/361579/0c50eddf570d/molcellb00034-0475-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1025/361579/5c04b742ef6a/molcellb00034-0476-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1025/361579/da52643ae447/molcellb00034-0476-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1025/361579/eee893db430c/molcellb00034-0477-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1025/361579/31415c7382ae/molcellb00034-0477-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1025/361579/e26e58fa2b57/molcellb00034-0478-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1025/361579/4c984dc162d1/molcellb00034-0474-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1025/361579/8faeb96f3f8b/molcellb00034-0474-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1025/361579/4a66b209f7c0/molcellb00034-0475-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1025/361579/0c50eddf570d/molcellb00034-0475-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1025/361579/5c04b742ef6a/molcellb00034-0476-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1025/361579/da52643ae447/molcellb00034-0476-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1025/361579/eee893db430c/molcellb00034-0477-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1025/361579/31415c7382ae/molcellb00034-0477-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1025/361579/e26e58fa2b57/molcellb00034-0478-a.jpg

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本文引用的文献

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Proteins crosslinked to messenger RNA by irradiating polyribosomes with ultraviolet light.通过用紫外线照射多核糖体与信使核糖核酸交联的蛋白质。
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Mouse RNAase MRP RNA is encoded by a nuclear gene and contains a decamer sequence complementary to a conserved region of mitochondrial RNA substrate.小鼠核糖核酸酶MRP RNA由一个核基因编码，并包含一个与线粒体RNA底物保守区域互补的十聚体序列。
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