Tanabe Kenneth K
Massachusetts General Hospital, Boston, MA 02114, USA.
Semin Oncol. 2006 Dec;33(6 Suppl 11):S39-41. doi: 10.1053/j.seminoncol.2006.10.010.
Techniques of liver resection for colorectal cancer metastases continue to evolve, and the range of patients who benefit from such treatment expands. With improvements in preoperative and intraoperative imaging, surgical strategies for reducing blood loss and maximizing excision of disease and residual liver function, patient selection, and chemotherapy, many of the traditional contraindications to hepatic resection are no longer absolute contraindications. Appreciable long-term survival after resection is observed in many patients for which resection would not have been considered an option until recently. Novel treatment strategies have been successful in converting nonresectable disease to resectable disease, with good survival outcome. Continued study of and experience with novel surgical techniques and treatment strategies will continue to improve outcomes in liver resection for metastatic colorectal cancer.
用于治疗结直肠癌肝转移的肝切除技术不断发展,受益于此类治疗的患者范围也在扩大。随着术前和术中成像技术的改进、减少失血和最大化疾病切除及保留残余肝功能的手术策略、患者选择以及化疗方面的进展,许多传统的肝切除禁忌证已不再是绝对禁忌证。在许多患者中观察到切除术后有可观的长期生存率,而直到最近,这些患者的切除手术都未被视为一种选择。新型治疗策略已成功地将不可切除的疾病转变为可切除的疾病,并取得了良好的生存结果。对新型手术技术和治疗策略的持续研究及经验积累将继续改善转移性结直肠癌肝切除的治疗效果。