Moura Mariela Dutra Gontijo, Guimarães Tatiane Roberta Morais, Fonseca Linaena Méricy Silva, de Almeida Pordeus Isabela, Mesquita Ricardo Alves
Oral Surgery, Medicine and Pathology Department, School of Dentistry, Federal University of Minas Gerais and Orestes Diniz's Treatment Center of Parasitic and Infectious Diseases, Minas Gerais, Brazil.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Jan;103(1):64-71. doi: 10.1016/j.tripleo.2006.02.016. Epub 2006 Jun 6.
The objective of this study was to assess the efficiency of topical applications of podophyllin resin (25%) (P) versus podophyllin resin (25%) together with acyclovir cream (5%) (PA) in the treatment of oral hairy leukoplakia (OHL) in accordance with the following criteria: (1) number of applications necessary for the total clinical resolution of OHL; (2) correlation between the decrease of lesion size and the number of applications; (3) total clinical resolution of OHL; and (4) clinical reevaluation 12 months after the end of treatment.
Forty-six OHLs were treated with P (P group) or with PA (PA group). Applications were performed weekly. Student t, Fisher exact, and Pearson correlation tests were used for statistical analysis.
All 24 lesions from the PA group presented total clinical resolution while 4 lesions from the P group did not. The P group required up to 25 applications performed weekly while the PA group required up to 18. Observed was a negative significant association between the size of the lesions and the number of applications performed weekly in the PA group.
The present study demonstrated the following: (1) P and PA topical treatments presented a similar average number of applications performed weekly; (2) both groups showed the same clinical response at 12 months post-therapy; and (3) PA presented a 100% clinical resolution and a continuous decrease in OHL size over the course of weekly applications.
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