PREDNOD，一种用于预测肽与非肥胖糖尿病小鼠H-2g7单倍型结合的服务器。

PREDNOD, a prediction server for peptide binding to the H-2g7 haplotype of the non-obese diabetic mouse.

作者信息

Rajapakse Menaka, Zhang Guang Lan, Srinivasan Kellathur N, Schmidt Bertil, Petrovsky Nikolai, Brusic Vladimir

机构信息

Institute for Infocomm Research, 21 Heng Mui Keng Terrace, Singapore, Singapore, 119613.

出版信息

Autoimmunity. 2006 Dec;39(8):645-50. doi: 10.1080/08916930601062494.

DOI:10.1080/08916930601062494

PMID:17178561

Abstract

The non-obese diabetic (NOD) mouse is a widely used animal model for study of autoimmune diseases, in particular human type 1 diabetes mellitus (T1DM). Identification of the subset of peptides that bind MHC molecules comprising the H-2g7 haplotype of NOD mouse and thereby representing potential NOD T-cell epitopes is important for research into the pathogenesis and immunotherapy of T1DM. The H-2g7 haplotype comprises the MHC class-I molecules Kd and Db and a single class-II molecule I-Ag7. We have developed a prediction system, PREDNOD, for accurate identification of peptides that bind the MHC molecules constituting the H-2g7 haplotype. PREDNOD is accessible at http://antigen.i2r.a-star.edu.sg/Ag7.

摘要

非肥胖型糖尿病（NOD）小鼠是一种广泛用于研究自身免疫性疾病，尤其是人类1型糖尿病（T1DM）的动物模型。鉴定与构成NOD小鼠H-2g7单倍型的MHC分子结合的肽段子集，从而确定潜在的NOD T细胞表位，对于T1DM发病机制和免疫治疗的研究具有重要意义。H-2g7单倍型由MHC I类分子Kd和Db以及单个II类分子I-Ag7组成。我们开发了一种预测系统PREDNOD，用于准确鉴定与构成H-2g7单倍型的MHC分子结合的肽段。可通过http://antigen.i2r.a-star.edu.sg/Ag7访问PREDNOD。