c-Fos基因缺陷型小鼠易受鼠伤寒沙门氏菌感染。
c-Fos-deficient mice are susceptible to Salmonella enterica serovar Typhimurium infection.
作者信息
Maruyama Kenta, Sano Gen-Ichiro, Ray Neelanjan, Takada Yasunari, Matsuo Koichi
机构信息
Department of Microbiology and Immunology, School of Medicine, Keio University, 160-8582 Tokyo, Japan.
出版信息
Infect Immun. 2007 Mar;75(3):1520-3. doi: 10.1128/IAI.01316-06. Epub 2006 Dec 18.
Abstract
c-Fos is a component of transcription factor AP-1. We show that macrophages lacking c-Fos exhibit enhanced production of proinflammatory cytokines, potentiated NF-kappaB phosphorylation, and increased cell death following Salmonella enterica serovar Typhimurium infection. Furthermore, mice lacking c-Fos are highly susceptible to infection, suggesting that c-Fos confers resistance to Salmonella infection in mice.
摘要
c-Fos是转录因子AP-1的一个组成部分。我们发现，缺乏c-Fos的巨噬细胞在感染鼠伤寒沙门氏菌后，促炎细胞因子的产生增加、NF-κB磷酸化增强且细胞死亡增加。此外，缺乏c-Fos的小鼠对感染高度敏感，这表明c-Fos赋予小鼠对沙门氏菌感染的抵抗力。
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