艾氏癌小鼠血红蛋白与血清蛋白相互作用的特点
Peculiarities of hemoglobin interaction with serum proteins of mice with Ehrlich carcinoma.
作者信息
Sitdikova S M, Amandzholov B S, Serebryakova M V, Zhdanovich M Yu, Kiselevskii M V, Donenko F V
机构信息
N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow.
出版信息
Bull Exp Biol Med. 2006 May;141(5):624-7. doi: 10.1007/s10517-006-0237-6.
In male C57Bl/6 mice with transplanted Ehrlich carcinoma, hemoglobin forms a complex with serum proteins characterized by a molecular weight of about 300 kDa. The complex incorporates proteins weighing 100, 68, 65, and 15 kDa identified by MALDI-TOF mass spectrometry as haptoglobin, serum albumin, gi/26341396 nameless protein Mus musculus, and alpha-hemoglobin, respectively. This complex can possess biological activity and contribute to the control of tumor growth.
在移植了艾氏癌的雄性C57Bl/6小鼠中，血红蛋白与血清蛋白形成一种分子量约为300 kDa的复合物。该复合物包含通过基质辅助激光解吸电离飞行时间质谱法鉴定为触珠蛋白、血清白蛋白、小家鼠gi/26341396无名蛋白和α-血红蛋白的100、68、65和15 kDa的蛋白质。这种复合物可能具有生物活性并有助于控制肿瘤生长。
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