具有强大抗缺血特性的新型基于苯并吡喃的线粒体ATP敏感性钾通道开放剂。
New benzopyran-based openers of the mitochondrial ATP-sensitive potassium channel with potent anti-ischemic properties.
作者信息
Breschi Maria C, Calderone Vincenzo, Martelli Alma, Minutolo Filippo, Rapposelli Simona, Testai Lara, Tonelli Federica, Balsamo Aldo
机构信息
Dipartimento di Scienze Farmaceutiche and Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Università di Pisa, Via Bonanno 6, I-56126 Pisa, Italy.
出版信息
J Med Chem. 2006 Dec 28;49(26):7600-2. doi: 10.1021/jm061228l.
This study was aimed at evaluating, on a limited number of benzopyran compounds, whether the insertion of an electron-rich spirocyclic substituent at the C4 carbon of the benzopyran molecular nucleus may improve the cardioprotective properties against ischemia. Some of the new compounds (1b, 2b, and 4b) exhibited interesting anti-ischemic properties without affecting significantly the blood pressure parameters.
本研究旨在评估在数量有限的苯并吡喃化合物中，在苯并吡喃分子核的C4碳上引入富电子螺环取代基是否可改善对缺血的心脏保护特性。一些新化合物（1b、2b和4b）表现出有趣的抗缺血特性，且对血压参数无显著影响。
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