手性硫脲——在不对称合成和药物化学中的制备及意义。
Chiral Thioureas-Preparation and Significance in Asymmetric Synthesis and Medicinal Chemistry.
机构信息
Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50 370 Wrocław, Poland.
Faculty of Chemistry, University of Wrocław, 14 F. Joliot-Curie St., 50 383 Wrocław, Poland.
出版信息
Molecules. 2020 Jan 18;25(2):401. doi: 10.3390/molecules25020401.
For almost 20 years, thioureas have been experiencing a renaissance of interest with the emerged development of asymmetric organocatalysts. Due to their relatively high acidity and strong hydrogen bond donor capability, they differ significantly from ureas and offer, appropriately modified, great potential as organocatalysts, chelators, drug candidates, etc. The review focuses on the family of chiral thioureas, presenting an overview of the current state of knowledge on their synthesis and selected applications in stereoselective synthesis and drug development.
近 20 年来，随着不对称有机催化剂的发展，硫脲重新引起了人们的兴趣。由于其相对较高的酸度和较强的氢键供体能力，它们与脲类有很大的不同，并具有作为有机催化剂、螯合剂、药物候选物等的巨大潜力，经过适当修饰。本文综述了手性硫脲的研究进展，概述了其合成方法及在立体选择性合成和药物开发中的应用。
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