癌症与抗α6整合素抗体的口腔类天疱疮患者之间的关系。
Relationship between cancer and oral pemphigoid patients with antibodies to alpha6-integrin.
作者信息
Malik Mohsin, Gürcan Hakan M, Christen William, Ahmed A Razzaque
机构信息
Department of Medicine, New England Baptist Hospital, Harvard School of Dental Medicine, Boston, MA, USA.
出版信息
J Oral Pathol Med. 2007 Jan;36(1):1-5. doi: 10.1111/j.1600-0714.2006.00483.x.
BACKGROUND
Mucous membrane pemphigoid is an autoimmune mucocutaneous blistering disease. A subset, known as anti-epiligrin cicatricial pemphigoid is associated with a high risk for malignancy. Oral pemphigoid (OP) is limited to the oral cavity. The purpose of this study was to determine the association between malignancy and patients with OP with antibodies to alpha6-integrin subunit.
METHODS
We determined the incidence of cancer in 72 patients with OP and compared it to the expected incidence using age and sex-specific rates of malignancy in the National Cancer Institute's Surveillance, Epidemiology, and End Results (NCI SEER) Registry.
RESULTS
During a mean observation period of 9.1 years (range: 2.8-40), for 70, three OP patients developed malignancies. The expected number of cancers based on the NCI SEER Registry was 8.83. The relative risk for cancer in OP patients, with autoantibodies to alpha6-integrin, was 0.34 (95% CI, 0.07-0.99, P < 0.05).
CONCLUSION
It appears that patients with OP, with antibodies to alpha6, may have a possible reduced relative risk for developing cancer.
背景
黏膜类天疱疮是一种自身免疫性黏膜皮肤水疱病。其中一个亚型，即抗表皮整联配体蛋白瘢痕性类天疱疮，与高恶性肿瘤风险相关。口腔类天疱疮（OP）局限于口腔。本研究的目的是确定OP患者中恶性肿瘤与抗α6整合素亚基抗体之间的关联。
方法
我们确定了72例OP患者的癌症发病率，并使用美国国立癌症研究所监测、流行病学和最终结果（NCI SEER）登记处的年龄和性别特异性恶性肿瘤发病率将其与预期发病率进行比较。
结果
在平均9.1年（范围：2.8 - 40年）的观察期内，70例OP患者中有3例发生恶性肿瘤。根据NCI SEER登记处，预期癌症病例数为8.83。OP患者中，具有抗α6整合素自身抗体的患者患癌的相对风险为0.34（95%置信区间，0.07 - 0.99，P < 0.05）。
结论
似乎具有抗α6抗体的OP患者发生癌症的相对风险可能降低。
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