Schlüter E, von Scholz I, Stutte H J
Virchows Arch A Pathol Anat Histol. 1975 Oct 30;368(3):205-12. doi: 10.1007/BF00432523.
Spindle-shaped acid-fast bodies have been identified only in lymph nodes till now. Their nature and their origin remained unclear. We have also found these bodies in the human spleen. Their staining reactions and their correlations to age, sex, weight of spleen, and to hemosiderin deposits were examined. They have been encountered in 50% of cases of hereditary spherocytosis and in 41.7% of cases of traumatic rupture of the spleen--but only in 2.3% of all other cases of groups of various other disorders. We conclude from our results that: 1. The spindle-shaped acid-fast bodies are made of ceroid. 2. They are not causative organisms and therefore cannot be of importance in the etiology of sarcoidosis. 3. They derive from increased destruction of erythrocytes. 4. They originate due to oxidative polymerization of membrane lipids. 5. They may also be found in absence of any fat-metabolism disturbance.
迄今为止，纺锤形抗酸小体仅在淋巴结中被发现。其性质和来源尚不清楚。我们在人类脾脏中也发现了这些小体。对它们的染色反应以及与年龄、性别、脾脏重量和含铁血黄素沉积的相关性进行了研究。在50%的遗传性球形红细胞增多症病例和41.7%的脾外伤性破裂病例中发现了它们，但在其他各种疾病组的所有其他病例中仅占2.3%。我们从结果中得出以下结论：1. 纺锤形抗酸小体由类蜡质组成。2. 它们不是致病生物体，因此在结节病的病因学中不重要。3. 它们源于红细胞破坏增加。4. 它们是由于膜脂质的氧化聚合而产生的。5. 在没有任何脂肪代谢紊乱的情况下也可能发现它们。
