天花疫苗接种三十多年后体液免疫和细胞免疫的持续存在。
The persistence of humoral and cellular immunities more than three decades after smallpox vaccination.
作者信息
Kim S-H, Yeo S-G, Park K-H, Bang J-W, Kim H-B, Kim N-J, Jee Y, Cho H, Oh M-D, Choe K-W
机构信息
Center for Infectious Diseases, National Institute of Health, Seoul, Republic of Korea.
出版信息
Clin Microbiol Infect. 2007 Jan;13(1):91-3. doi: 10.1111/j.1469-0691.2006.01576.x.
This study assessed the persistence of humoral (neutralising antibody titre to vaccinia virus) and cellular (immediate vaccinia-specific interferon (IFN)-gamma-producing T-cell) immunities to smallpox in a Korean population. Individuals who were vaccinated 25-60 years previously had higher neutralising antibody titres (geometric mean titre (GMT) 13.7; 95% CI 11.0-17.2) than vaccinia-naive individuals (GMT 6.7; 95% CI 5.5-8.0; p <0.001). However, there was no significant difference in cellular immunity between individuals vaccinated previously and vaccinia-naive individuals, and only 15% of the individuals vaccinated previously displayed an immediate IFN-gamma-producing effector-memory response in ELISPOT assays.
本研究评估了韩国人群中针对天花的体液免疫（抗痘苗病毒中和抗体滴度）和细胞免疫（痘苗特异性即刻产生γ干扰素的T细胞）的持久性。25至60年前接种过疫苗的个体的中和抗体滴度（几何平均滴度（GMT）为13.7；95%置信区间为11.0 - 17.2）高于未接种过痘苗的个体（GMT为6.7；95%置信区间为5.5 - 8.0；p<0.001）。然而，既往接种过疫苗的个体与未接种过痘苗的个体在细胞免疫方面没有显著差异，并且在ELISPOT检测中，既往接种过疫苗的个体中只有15%表现出即刻产生γ干扰素的效应记忆反应。
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