使用稀释的灭活痘苗疫苗溶液进行皮肤试验来测定对痘苗病毒的免疫力。
Determination of immunity to vaccinia virus by using diluted inactivated vaccinia vaccine solution for skin testing.
作者信息
Somekh Eli, Smetana Zahava, Tanay Amir, Dalal Ilan, Babai Ilan, Mendelson Ella
机构信息
The Section of Pediatric Infectious Diseases and Immunology, The Edith Wolfson Medical Center, P.O. Box 5, Holon and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
出版信息
Vaccine. 2004 Dec 2;23(3):321-4. doi: 10.1016/j.vaccine.2004.06.005.
AIMS
We evaluated the usefulness of skin test prepared by inactivation of vaccinia vaccine in predicting immunity to vaccinia. Skin test was injected to 77 healthy adults. Twenty had a recent smallpox vaccination (group 1). Thirty-seven were long term vacinees (group 2), while 20 subjects had never been vaccinated for smallpox (group 3).
RESULTS
Mean size of induration was 7.9, 5.3 and 0.4 mm for subjects from groups 1, 2 and 3, respectively (P<0.03 for difference between groups). Induration >or=5 mm correlated with neutralizing antibody titer >1:32 (r=0.73, P<0.0001).
CONCLUSIONS
The skin test is a potentially useful tool for the assessment of immunity to vaccinia.
目的
我们评估了通过灭活痘苗疫苗制备的皮肤试验在预测痘苗免疫方面的实用性。对77名健康成年人进行了皮肤试验注射。20人近期接种过天花疫苗（第1组）。37人是长期接种者（第2组），而20名受试者从未接种过天花疫苗（第3组）。
结果
第1、2和3组受试者的硬结平均大小分别为7.9、5.3和0.4毫米（组间差异P<0.03）。硬结≥5毫米与中和抗体滴度>1:32相关（r=0.73，P<0.0001）。
结论
皮肤试验是评估痘苗免疫的一种潜在有用工具。
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