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静脉注射对乙酰氨基酚用于一名4日龄足月儿的术后镇痛。

Intravenous paracetamol for postoperative analgesia in a 4-day-old term neonate.

作者信息

Agrawal Shruti, Fitzsimons John J, Horn Venetia, Petros Andy

机构信息

NICU and Pharmacy Department, Great Ormond Street Hospital, London WC1N 3JH, UK.

出版信息

Paediatr Anaesth. 2007 Jan;17(1):70-1. doi: 10.1111/j.1460-9592.2006.02004.x.

Abstract

There are only a few clinical reports on the use of intravenous (i.v.) paracetamol in term neonates. This case report illustrates that when routes for administration of analgesics are restricted to i.v. only and when opioids are not indicated then i.v. paracetamol may be used. In our 4-day-old term infant, despite i.v. paracetamol for 48 h, the trough level during therapy was almost undetectable indicating rapid clearance. Although i.v. paracetamol is not licensed in this age group, it can prove very helpful when the only route of administration is intravenous.

摘要

关于足月儿静脉注射对乙酰氨基酚的临床报告仅有少数几例。本病例报告表明,当镇痛药物的给药途径仅限于静脉注射且未指明使用阿片类药物时,可使用静脉注射对乙酰氨基酚。在我们的4日龄足月儿中,尽管静脉注射对乙酰氨基酚达48小时,但治疗期间的谷浓度几乎检测不到,表明清除迅速。虽然静脉注射对乙酰氨基酚在该年龄组未获许可,但当唯一的给药途径是静脉注射时,它可能非常有用。

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