产前危险因素、细胞因子与儿童早期特应性疾病的发生发展
Antenatal risk factors, cytokines and the development of atopic disease in early childhood.
作者信息
Chung E K, Miller R L, Wilson M T, McGeady S J, Culhane J F
机构信息
The Division of General Pediatrics, Department of Pediatrics, Jefferson Medical College, Philadelphia, Pennsylvania, USA.
出版信息
Arch Dis Child Fetal Neonatal Ed. 2007 Jan;92(1):F68-73. doi: 10.1136/adc.2006.106492.
Abstract
Atopic diseases are complex entities influenced by an array of risk factors, including genetic predisposition, environmental allergens, antenatal exposures, infections and psychosocial factors. One proposed mechanism by which these risk factors contribute to the development of atopic disease is through changes in the production of T helper cell type 1 (Th1) and T helper cell type 2 (Th2) cytokines. The objectives of this review are to discuss antenatal exposures that are associated with paediatric atopic diseases, to discuss the influence of the intrauterine environment on neonatal immune responses, to provide an overview of the Th1 and Th2 pathways and how they relate to atopic disease, and to summarise our current understanding of the association between cytokine responses in cord blood and the development of atopic disease in early childhood.
摘要
特应性疾病是受一系列风险因素影响的复杂实体，这些因素包括遗传易感性、环境过敏原、产前暴露、感染和心理社会因素。这些风险因素导致特应性疾病发生的一种推测机制是通过1型辅助性T细胞（Th1）和2型辅助性T细胞（Th2）细胞因子产生的变化。本综述的目的是讨论与儿童特应性疾病相关的产前暴露，讨论子宫内环境对新生儿免疫反应的影响，概述Th1和Th2途径及其与特应性疾病的关系，并总结我们目前对脐血中细胞因子反应与幼儿特应性疾病发展之间关联的理解。
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