Department of Environmental Immunology, UFZ, Helmholtz Centre for Environmental Research Leipzig, Germany.
Allergy. 2011 Aug;66(8):1065-74. doi: 10.1111/j.1398-9995.2011.02587.x. Epub 2011 Mar 28.
The influence of maternal immune responses in pregnancy on children's immune competence and the development of atopic diseases later in life are poorly understood. To determine potential maternal effects on the maturation of children's immune system and resulting disease risks, we analysed immune responses in mother-child pairs in a prospective birth cohort study.
Within the Lifestyle and Environmental factors and their Influence on Newborns Allergy risk (LINA) study, concentrations of Th1/Th2/Th17 and inflammatory cytokines/chemokines as well as IgE were measured in phytohemagglutinin and lipopolysaccharide stimulated maternal blood in the 34th week of gestation and in corresponding children's blood at birth and 1 year after (n = 353 mother-child pairs). Information on atopic outcomes during the first year of life was obtained from questionnaires.
Concentrations of inflammatory markers, excepting TNF-α, were manifold higher in cord blood samples compared with maternal blood. Th1/Th2 cytokines were lower in children's blood with a Th2 bias at birth. Maternal inflammatory parameters (MCP-1, IL-10, TNF-α) in pregnancy showed an association with corresponding cytokines blood levels in children at the age of one. High maternal IgE concentrations in pregnancy were associated with increased children's IgE at birth and at the age of one, whereas children's atopic dermatitis (AD) was determined by maternal AD.
Maternal inflammatory cytokines during pregnancy correlate with children's corresponding cytokines at the age of one but are not related to IgE or AD. While maternal IgE predicts children's IgE, AD in children is only associated with maternal disease.
母体在妊娠期间的免疫反应对儿童的免疫能力以及日后特应性疾病的发展影响尚不清楚。为了确定母体对儿童免疫系统成熟的潜在影响以及由此产生的疾病风险，我们在一项前瞻性出生队列研究中分析了母婴对的免疫反应。
在生活方式和环境因素及其对新生儿过敏风险的影响（LINA）研究中，我们在妊娠第 34 周测量了植物血球凝集素和脂多糖刺激的母体血液中的 Th1/Th2/Th17 和炎症细胞因子/趋化因子以及 IgE 的浓度，并在出生时和 1 岁时测量了相应的儿童血液（n=353 对母婴）。从问卷调查中获得了儿童生命第一年特应性结局的信息。
除 TNF-α外，脐带血样本中的炎症标志物浓度比母体血液高几倍。儿童血液中的 Th1/Th2 细胞因子在出生时呈 Th2 偏倚。妊娠期间的母体炎症参数（MCP-1、IL-10、TNF-α）与儿童 1 岁时相应细胞因子的血液水平相关。妊娠期间母体 IgE 浓度高与儿童出生时和 1 岁时 IgE 升高相关，而儿童特应性皮炎（AD）则由母亲 AD 决定。
妊娠期间母体炎症细胞因子与儿童 1 岁时相应的细胞因子相关，但与 IgE 或 AD 无关。虽然母体 IgE 预测儿童 IgE，但儿童 AD 仅与母体疾病相关。
