Spinocerebellar projection in the meander tail mutant mouse: organization in the granular posterior lobe and the agranular anterior lobe.

The cerebellum of the mutant mouse, meander tail, is characterized by normal cytoarchitecture posteriorly and abnormal, agranular cortex anteriorly. Anterograde WGA-HRP tracing analysis of the spinocerebellar projection reveals typical mossy fiber labeling posteriorly in lobule VIII. However, in the anterior cortex, a finer, more diffuse pattern of labeling is seen, unlike the distinct banded pattern of mossy fiber rosettes which characterizes the spinocerebellar projection in the normal animal.