Lê P, Mehtari L, Billey C
Service de Chirurgie Générale, Centre Hospitalier de l'Agglomération Montargoise, Montargis.
J Chir (Paris). 2006 Sep-Oct;143(5):285-93. doi: 10.1016/s0021-7697(06)73693-6.
Carcinoma of the transverse colon accounts for 10% of all colorectal cancer. Diagnosis is often delayed and complicated forms (perforation, fistulization, obstruction) occur in 30-50% of cases. The progression of symptoms is often insidious and tumors may be voluminous by the time of diagnosis. Right sided tumors are typically bulky and late-stage; perforation may lead to abdominal wall or retroperitoneal abscess. Tumor can also extend or fistulize into adjacent organs. Distal transverse cancers may be small annular lesions which are prone to obstruction. Cancers present as T4 lesions in 20-40% of cases. Abdominal CT is the best test to evaluate the loco-regional extension of advanced tumors. Their central location and advanced stage at presentation results in an extensive differential diagnosis. This central location also poses difficult surgical choices for lymph node dissection, extent of resection, and re-establishment of intestinal continuity. Surgical series which focus on transverse colon cancer date from the 1970-80's; they show curative resections in only 50% with morbidity/mortality of 20% and a global five year survival of less than 35%; they were considered to have a particularly poor prognosis.
横结肠癌占所有结直肠癌的10%。诊断往往延迟,30%-50%的病例会出现复杂形式(穿孔、瘘管形成、梗阻)。症状进展通常隐匿,诊断时肿瘤可能已体积较大。右侧肿瘤通常体积大且处于晚期;穿孔可能导致腹壁或腹膜后脓肿。肿瘤也可扩展或形成瘘管至相邻器官。远端横结肠癌可能是小的环形病变,易于梗阻。20%-40%的病例中癌症表现为T4病变。腹部CT是评估晚期肿瘤局部区域扩展的最佳检查。它们的中心位置和就诊时的晚期阶段导致广泛的鉴别诊断。这个中心位置也给淋巴结清扫、切除范围和肠道连续性重建的手术选择带来困难。专注于横结肠癌的手术系列研究始于20世纪70-80年代;它们显示仅50%的病例可进行根治性切除,发病率/死亡率为20%,总体五年生存率低于35%;它们被认为预后特别差。