Caruthers M H, Beaton G, Cummins L, Graff D, Ma Y X, Marshall W S, Sasmor H, Norris P, Yau E K
Department of Chemistry and Biochemistry, University of Colorado, Boulder 80309-0215.
Ciba Found Symp. 1991;158:158-66; discussion 166-8. doi: 10.1002/9780470514085.ch11.
Dithioate DNA was synthesized and used for various biochemical studies. Results from these studies indicate that dithioate DNA is a potent inhibitor of HIV Reverse Transcriptase, activates endogenous RNase H in HeLa cell nuclear extracts, and is a useful probe for studying protein-DNA interactions.
