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溶瘤梭菌治疗后艾氏腹水实体瘤的激肽酶活性

The kininase activity of Ehrlichs' ascites solid tumor after treatment with oncolytic clostridia.

作者信息

Fischer G, Brantner H, Platzer P

出版信息

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1975 Oct 27;84(2):203-6. doi: 10.1007/BF00304045.

DOI:10.1007/BF00304045
PMID:171870
Abstract

For the first time the effect of bacterial kininases of Cl. oncolyticum M 55 ATCC 13.732 could be demonstrated in the tumor itself. This is shown by an increased degradation of kinins by spore-treated tumor tissue in comparison with respective controls. The results indicate the influence of kininases on the capillary circulation of the tumor tissue as one of the fundamental reactions of oncolysis.

摘要

首次在肿瘤本身中证实了溶瘤梭菌M 55 ATCC 13.732的细菌激肽酶的作用。与相应对照相比，经孢子处理的肿瘤组织中激肽降解增加即表明了这一点。结果表明，激肽酶对肿瘤组织毛细血管循环的影响是溶瘤的基本反应之一。

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The kininase activity of Ehrlichs' ascites solid tumor after treatment with oncolytic clostridia.溶瘤梭菌治疗后艾氏腹水实体瘤的激肽酶活性
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1975 Oct 27;84(2):203-6. doi: 10.1007/BF00304045.
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本文引用的文献

1
[The influence of ellagic acid on the oncolytic effect of clostridium M55 (author's transl)].
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1974;82(2):143-52. doi: 10.1007/BF00284499.
2
[Examination of the kininases in an oncolytic Clostridium (Strain M55ATCC13732) by means of chelate-forming agents].
Pathol Microbiol (Basel). 1973;39(2):99-106.
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[Enzyme studies on a clostridium strain (Cl. butyricum M55) with oncolytic action].
Zentralbl Bakteriol Orig A. 1972 May;220(1):432-4.
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[Bacterial kininases and their physiological importance. I. Studies on Clostridia strains].
Zentralbl Bakteriol Orig A. 1972 Apr;219(4):530-41.
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[The effect of Clostridium butyricum (strain M 55) on human kininogen and its significance for the process of oncolysis].
Zentralbl Bakteriol Orig A. 1972 Sep;221(4):474-91.
6
[Studies on the culture of clostridium butyricum strain M 55 ATCC 13.732. 4th Communication: The influence of peptone quality upon kininase activity (author's transl)].
Zentralbl Bakteriol Orig A. 1975;230(2):241-5.