Zimmermann A, Dirrigl A, Heider P, Metz S, Eckstein H-H
Abteilung für Gefässchirurgie, Klinikum rechts der Isar, Technische Universität München, München.
Dtsch Med Wochenschr. 2007 Jan 5;132(1-2):21-4. doi: 10.1055/s-2007-959282.
A 24-year-old patient presented with nonspecific epigastric pain, general feebleness and weakness of both legs. The cardiopulmonary investigations were unremarkable. The abdomen was soft, without muscular resistance or local pressure tenderness. Both legs were moderately swollen without other findings.
The laboratory tests showed an elevated D-dimer and fibrinogen, as well as a heterozygous factor V Leiden mutation. Both duplex ultrasonography and computed tomography revealed thrombosis of the distal inferior vena cava (IVC) and both iliac and femoral veins. A short segment of the IVC between the left renal and intrahepatic veins was a-genetic.
DIAGNOSIS, TREATMENT AND COURSE: Anticoagulation treatment with phenprocoumon was started for the deep vein thrombosis. At the one-year follow-up no thrombosis of the vena cava and the iliac and femoral veins was detected.
Thrombosis of the IVC in combination with a pelvic vein thrombosis is a rare condition in young patients. If this venous abnormality is found, thrombophilia should be considered in the differential diagnosis. Anticoagulation is the treatment of choice.
一名24岁患者出现非特异性上腹部疼痛、全身乏力及双腿无力。心肺检查无异常。腹部柔软,无肌紧张或局部压痛。双腿中度肿胀,无其他异常发现。
实验室检查显示D - 二聚体和纤维蛋白原升高,以及杂合子因子V莱顿突变。双功超声和计算机断层扫描均显示下腔静脉远端及双侧髂静脉和股静脉血栓形成。左肾静脉与肝内静脉之间的一小段下腔静脉缺如。
诊断、治疗及病程:针对深静脉血栓形成开始使用苯丙香豆素进行抗凝治疗。在一年的随访中,未检测到腔静脉及髂静脉和股静脉血栓形成。
年轻患者中下腔静脉血栓形成合并盆腔静脉血栓形成是一种罕见情况。如果发现这种静脉异常,在鉴别诊断中应考虑易栓症。抗凝是首选治疗方法。