骨形态发生蛋白在心脏分化中的作用。

Role of bone morphogenetic proteins in cardiac differentiation.

作者信息

van Wijk Bram, Moorman Antoon F M, van den Hoff Maurice J B

机构信息

Molecular and Experimental Cardiology Group, Department of Anatomy and Embryology, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands.

出版信息

Cardiovasc Res. 2007 May 1;74(2):244-55. doi: 10.1016/j.cardiores.2006.11.022. Epub 2006 Nov 21.

DOI:10.1016/j.cardiores.2006.11.022

PMID:17187766

Abstract

Bone morphogenetic proteins (BMP) are involved in the regulation of a plethora of processes underlying cardiovascular development. This review summarizes the effects of BMP and the signaling pathways that regulate the differentiation of cardiomyocytes from mesoderm in the heart-forming region and at the distal borders of the heart tube from the second heart field. Subsequently, the role of BMPs in the formation of the ventricular chambers and septovalvulogenesis in the atrioventricular canal and outflow tract is described. Finally, the effects of BMPs in stem cell biology and cardiac regeneration are discussed.

摘要

骨形态发生蛋白（BMP）参与了心血管发育过程中众多过程的调控。本综述总结了BMP的作用以及调节中胚层来源的心肌细胞在心脏形成区域和来自第二心脏场的心脏管远端边界处分化的信号通路。随后，描述了BMP在心室腔形成以及房室管和流出道的间隔瓣膜发生中的作用。最后，讨论了BMP在干细胞生物学和心脏再生中的作用。