限制型神经性厌食症患者的血浆总胃饥饿素水平。
Total ghrelin plasma level in patients with the restrictive type of anorexia nervosa.
作者信息
Janas-Kozik Malgorzata, Krupka-Matuszczyk Irena, Malinowska-Kolodziej Izabela, Lewin-Kowalik Joanna
机构信息
Department and Clinic of Psychiatry and Psychotherapy, Medical University of Silesia, Katowice, ul. Ziolowa 45/47, 40-635 Katowice, Poland.
出版信息
Regul Pept. 2007 Apr 5;140(1-2):43-6. doi: 10.1016/j.regpep.2006.11.005. Epub 2006 Dec 21.
Ghrelin is produced mainly in the stomach and is an essential link of the brain-gut axis. Ghrelin stimulates hunger centers in hypothalamus controlling food intake and body mass gain. The aim of the study is to analyze the total ghrelin plasma level in patients suffering from restrictive type of anorexia nervosa (AN-R). According to DSM-IV classification a group of 30 AN-R patients was investigated before and after 3 and 6 months of therapy. Therapy included normocaloric diet and cognitive-behavioral psychotherapy (CBT). The control group consisted of 20 girls without any eating disorders. Before the therapy the total ghrelin plasma level in AN-R patients was significantly higher than in the control group. After 3 and 6 months of treatment the total ghrelin plasma level in AN-R patients was significantly lower than in the control group. In AN-R patients, the total ghrelin plasma level is connected with the pathological feeding behavior.
胃饥饿素主要在胃中产生，是脑-肠轴的重要环节。胃饥饿素刺激下丘脑的饥饿中枢，控制食物摄入和体重增加。本研究的目的是分析患有限制型神经性厌食症（AN-R）患者的血浆总胃饥饿素水平。根据《精神疾病诊断与统计手册》第四版（DSM-IV）分类，对一组30例AN-R患者在治疗前以及治疗3个月和6个月后进行了调查。治疗包括正常热量饮食和认知行为心理治疗（CBT）。对照组由20名无任何饮食失调的女孩组成。治疗前，AN-R患者的血浆总胃饥饿素水平显著高于对照组。治疗3个月和6个月后，AN-R患者的血浆总胃饥饿素水平显著低于对照组。在AN-R患者中，血浆总胃饥饿素水平与病理性进食行为有关。
Zotero 插件