当细胞周期蛋白依赖性激酶1（CDK1）经历端粒循环时。

When CDK1 rides the telomere cycle.

作者信息

Teixeira M Teresa, Gilson Eric

机构信息

Laboratoire de Biologie Moléculaire de la Cellule of Ecole Normale Supérieure de Lyon, UMR CNRS/INRA/ENS, IFR 128 BioSciences Lyon Gerland, 46 Allée d'Italie, 69364 Lyon Cedex 07, France.

出版信息

Mol Cell. 2006 Nov 17;24(4):491-2. doi: 10.1016/j.molcel.2006.10.033.

DOI:10.1016/j.molcel.2006.10.033

PMID:17188029

Abstract

Reconstitution of telomeric DNA at each cell division implies the coordination of DNA semiconservative replication with several processing events still poorly understood. Two reports published recently in Molecular Cell show that a cell-cycle cyclin-dependent kinase, Cdk1p, is required to create the cell-cycle-regulated overhang ().

摘要

在每次细胞分裂时端粒DNA的重建意味着DNA半保留复制与几个仍了解甚少的加工事件之间的协调。最近发表在《分子细胞》上的两篇报道表明，细胞周期蛋白依赖性激酶Cdk1p是产生细胞周期调控的突出端所必需的。