增殖性糖尿病视网膜病变患者玻璃体内白细胞介素-8水平
Vitreous levels of interleukin-8 in patients with proliferative diabetic retinopathy.
作者信息
Petrovic Mojca Globocnik, Korosec Peter, Kosnik Mitja, Hawlina Marko
机构信息
University Eye Clinic, Medical Centre Ljubljana, Zaloska 29a, 1000 Ljubljana, Slovenia.
出版信息
Am J Ophthalmol. 2007 Jan;143(1):175-6. doi: 10.1016/j.ajo.2006.07.032. Epub 2006 Sep 1.
PURPOSE
To determine the levels of interleukin 8 (IL-8) in the vitreous of patients with proliferative diabetic retinopathy (PDR).
DESIGN
Observational case-control study.
METHODS
Vitreous fluid samples were obtained by vitreoretinal surgery from 71 eyes of patients with diabetes mellitus type 2 with PDR and from 17 eyes of nondiabetic patients with a macular hole. PDR was classified as active and inactive and subdivided according to the extent of large-vessel gliotic obliteration. The cytokine levels were measured by cytometric bead array method.
RESULTS
The vitreous levels of IL-8 were significantly higher in patients with PDR in comparison with the control subjects (P < .001) and in patients with higher extent of large vessel gliotic obliteration (P < .001). A vitreous level of IL-8 was not associated with the presence of active PDR.
CONCLUSION
Increased levels of IL-8 in PDR were associated with a higher extent of large-vessel gliotic obliteration.
目的
测定增殖性糖尿病视网膜病变（PDR）患者玻璃体内白细胞介素8（IL-8）的水平。
设计
观察性病例对照研究。
方法
通过玻璃体视网膜手术从71例2型糖尿病伴PDR患者的眼中以及17例非糖尿病黄斑裂孔患者的眼中获取玻璃体液样本。PDR分为活动期和非活动期，并根据大血管胶质化闭塞的程度进一步细分。采用细胞计数珠阵列法测量细胞因子水平。
结果
与对照组相比，PDR患者玻璃体内IL-8水平显著更高（P <.001），且在大血管胶质化闭塞程度较高的患者中也显著更高（P <.001）。玻璃体内IL-8水平与活动期PDR的存在无关。
结论
PDR中IL-8水平升高与大血管胶质化闭塞程度较高有关。
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