Gilli S C, De Paula E V, Biscaro F P, Marques J F, Costa F F, Saad S T
Hematology and Hemotherapy Center, State University of Campinas, Campinas, SP, Brazil.
Int J Gynaecol Obstet. 2007 Jan;96(1):8-11. doi: 10.1016/j.ijgo.2006.09.017. Epub 2006 Dec 22.
To evaluate the effects of prophylactic transfusion by means of erythrocytapheresis at the beginning of the third trimester of pregnancy in women with sickle cell disease (SCD).
A cohort of 14 pregnant women with SCD who received prophylactic erythrocytapheresis transfusions at the beginning of the third trimester was retrospectively compared with a cohort of 17 pregnant women who received simple prophylactic transfusions for no indication other than SCD severity.
Prophylactic erythrocytapheresis transfusions were associated with a lower risk of intrauterine growth restriction (OR, 0.11; 95% confidence interval, 0.01-1.00) and oligohydramnios (OR, 0.65; 95% confidence interval, 0.45-0.92) in pregnant women with SCD.
These results suggest that erythrocytapheresis transfusions are beneficial in women with SCD who are in the third trimester of pregnancy. Given the decrease in transfusion risks, this therapy deserves further evaluation in future trials.
评估妊娠晚期开始时通过红细胞单采进行预防性输血对镰状细胞病（SCD）女性患者的影响。
回顾性比较了一组14名在妊娠晚期开始时接受预防性红细胞单采输血的SCD孕妇与一组17名除SCD严重程度外无其他指征而接受单纯预防性输血的孕妇。
预防性红细胞单采输血与SCD孕妇发生宫内生长受限的风险较低（比值比，0.11；95%置信区间，0.01 - 1.00）和羊水过少（比值比，0.65；95%置信区间，0.45 - 0.92）相关。
这些结果表明，红细胞单采输血对处于妊娠晚期的SCD女性有益。鉴于输血风险降低，这种疗法值得在未来试验中进一步评估。
