Sabherwal Yamini, Rothman Vicki L, Poon Ronnie T P, Tuszynski George P
Center for Neurovirology, Department of Neuroscience, Temple University, Philadelphia, PA 19122, USA.
Cancer Lett. 2007 Jun 18;251(1):28-35. doi: 10.1016/j.canlet.2006.10.023. Epub 2006 Dec 22.
Angiocidin, a tumor-secreted protein, was measured in serum of 27 healthy volunteers and 33 hepatocellular carcinoma (HCC) patients. Healthy controls either hepatitis B surface antigen (HBsAg) positive or negative showed undetectable levels. Patients had levels of angiocidin ranging from 15.09 to 195.73 pg/ml. Patients with stages III-IV had higher levels of angiocidin (97+/-13 pg/ml, n=17) compared to those with stages I-II (63+/-37 pg/ml, n=16), p<0.043. Patients with microsatellite tumor nodules had higher average levels (98+/-55 pg/ml, n=17) compared to those without microsatellite nodules (51+/-27 pg/ml, n=20), p<0.032. Our studies suggest that angiocidin predicts advanced stage and intra-hepatic metastasis.
血管抑素是一种肿瘤分泌蛋白,在27名健康志愿者和33名肝细胞癌(HCC)患者的血清中进行了检测。健康对照者,无论乙肝表面抗原(HBsAg)阳性或阴性,血管抑素水平均检测不到。患者的血管抑素水平在15.09至195.73 pg/ml之间。与I-II期患者(63±37 pg/ml,n = 16)相比,III-IV期患者的血管抑素水平更高(97±13 pg/ml,n = 17),p<0.043。有微卫星肿瘤结节的患者平均水平(98±55 pg/ml,n = 17)高于无微卫星结节的患者(51±27 pg/ml,n = 20),p<0.032。我们的研究表明,血管抑素可预测晚期和肝内转移。