Fukuda T, Akutsu I, Motojima S, Makino S
Department of Internal Medicine, Dokkyo University School of Medicine, Tochigi, Japan.
Int Arch Allergy Appl Immunol. 1991;94(1-4):259-61. doi: 10.1159/000235377.
Using a guinea pig model of asthma, we have shown that the administration of cyclosporin, a T-lymphocyte-selective immunosuppressive agent, from the beginning of the immunization period inhibits the development of the late asthmatic response and bronchial hyperresponsiveness after antigen challenge. Similar results were obtained with FK 506, a new potent immunosuppressive agent. Since these compounds have been shown to suppress the activation of guinea pig T lymphocytes, the present data suggest that T lymphocytes may be important for the elicitation of the late asthmatic response and bronchial hyperresponsiveness.
利用哮喘豚鼠模型，我们已证明，从免疫期开始给予环孢素（一种T淋巴细胞选择性免疫抑制剂）可抑制抗原激发后迟发性哮喘反应和支气管高反应性的发展。新型强效免疫抑制剂FK 506也得到了类似结果。由于这些化合物已被证明可抑制豚鼠T淋巴细胞的活化，目前的数据表明，T淋巴细胞可能在迟发性哮喘反应和支气管高反应性的诱发中起重要作用。
