用于微生物检测与鉴定的新型显色氨肽酶底物的合成与评价
Synthesis and evaluation of novel chromogenic aminopeptidase substrates for microorganism detection and identification.
作者信息
James Arthur L, Perry John D, Rigby Annette, Stanforth Stephen P
机构信息
School of Applied Sciences, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK.
出版信息
Bioorg Med Chem Lett. 2007 Mar 1;17(5):1418-21. doi: 10.1016/j.bmcl.2006.11.088. Epub 2006 Dec 3.
PMID:17189689
Abstract
The amides 8a-e and 10a-c were prepared as chromogenic aminopeptidase substrates. A range of microorganisms were grown in the presence of these compounds and coloured colonies were produced in several cases after addition of acetic acid-thus giving potential methods for the detection of aminopeptidase activity and for microorganism identification.
摘要
酰胺8a - e和10a - c被制备为显色氨肽酶底物。一系列微生物在这些化合物存在的情况下生长，并且在加入乙酸后，有几种情况下产生了有色菌落——从而为氨肽酶活性的检测和微生物鉴定提供了潜在方法。
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