Su Jian-An, Wu Chien-Hui, Tsang Hin-Yeung
Department of Psychiatry, Chang Gung Memorial Hospital, Chia Yi Shen 61344, Taiwan, R.O.C.
Gen Hosp Psychiatry. 2007 Jan-Feb;29(1):75-7. doi: 10.1016/j.genhosppsych.2006.10.011.
Systemic lupus erythematosus (SLE) patients may have psychiatric manifestations during the illness course. Psychotropic agents are indicated in treating these symptoms. Second-generation antipsychotics, such as risperidone, olanzapine and quetiapine, have been thought to be safer than clozapine with regard to the side effect of neutropenia or agranulocytosis. We report a case of SLE who developed agranulocytosis during the treatment with olanzapine for the SLE-related psychiatric symptoms.
系统性红斑狼疮（SLE）患者在病程中可能会出现精神症状。治疗这些症状时需使用精神药物。第二代抗精神病药物，如利培酮、奥氮平和喹硫平，在中性粒细胞减少或粒细胞缺乏症的副作用方面被认为比氯氮平更安全。我们报告一例SLE患者，在用奥氮平治疗与SLE相关的精神症状期间发生了粒细胞缺乏症。
