Ashizawa Tatsuto, Okada Ryosuke, Suzuki Yoshiaki, Takagi Makoto, Yamazaki Tatsuyuki, Sumi Tetsuo, Aoki Toshiaki, Aoki Tatsuya
Department of Surgery, Hachioji Medical Center of Tokyo Medical University, Hachioji, Tokyo 193-0998, Japan.
Acta Med Okayama. 2006 Dec;60(6):325-30. doi: 10.18926/AMO/30723.
We investigated the diagnostic significance of IL-6 for lymph node metastasis and/or hepatic metastasis from colorectal cancer in 65 patients and evaluated the contributions of 8 factors (IL-6, HGF, IL-1beta, TNF-alpha, TGF-beta1, ELAM-1, ICAM-1, VCAM-1) toward Dukes.s classification of 53 patients. We also examined IL-6 expression in tumor tissue. From the receiver operating characteristic (ROC) curve analysis, an optimal cutoff value of 5.8 pg/ml was determined to classify lymph node and/or hepatic metastasis, and that of 6.3 pg/ml was determined to classify hepatic metastasis. These values indicated sensitivities of 55.0% and 71.4%, and specifi cities of 100% and 88.6%, respectively. IL-6, HGF, and ELAM-1 were very useful for distinguishing among Dukes.s A/B group, C group, and D group. In all cases with high IL-6 values (more than 25.0 pg/ml), immunohistochemical staining was positive for IL-6 in the cytoplasm of cancer cells. IL-6 is strongly suspected to be involved in lymph node and/or hepatic metastasis by promoting it through HGF, and serum IL-6 value (pg/ml) would be useful diagnostically to estimate whether or not there is a high risk of lymph node and/or hepatic metastasis.
我们研究了白细胞介素-6（IL-6）对65例结直肠癌患者淋巴结转移和/或肝转移的诊断意义，并评估了8种因子（IL-6、肝细胞生长因子（HGF）、白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）、转化生长因子-β1（TGF-β1）、内皮细胞白细胞黏附分子-1（ELAM-1）、细胞间黏附分子-1（ICAM-1）、血管细胞黏附分子-1（VCAM-1））对53例患者Dukes分期的作用。我们还检测了肿瘤组织中IL-6的表达。通过受试者工作特征（ROC）曲线分析，确定将淋巴结和/或肝转移分类的最佳截断值为5.8 pg/ml，将肝转移分类的最佳截断值为6.3 pg/ml。这些值分别显示敏感性为55.0%和71.4%，特异性为100%和88.6%。IL-6、HGF和ELAM-1对区分Dukes A/B组、C组和D组非常有用。在所有IL-6值高（超过25.0 pg/ml）的病例中，癌细胞胞质中IL-6的免疫组化染色呈阳性。强烈怀疑IL-6通过HGF促进淋巴结和/或肝转移，血清IL-6值（pg/ml）在诊断上有助于评估是否存在淋巴结和/或肝转移的高风险。
