Zaĭtseva N V, Zemlianova M A, Shur P Z, Kir'ianov D A
Gig Sanit. 2006 Nov-Dec(6):21-3.
To form the evidence base of the "environmental determination" of disease is a topical line in human ecology and environmental hygiene. The widespread use of monohydric aliphatic alcohols in industry has determined the necessity of making an in-depth study of their toxic effects on man, by taking into account their actual concentrations forming in the blood. The results of the studies have led to the conclusion that the real risk of toxic exposure of an organism to monohydric alcohols forms when the blood concentrations of butyl alcohols, propyl alcohols, and methyl alcohol are over 0.03, 1.0-1.5, and 0.5 microg/kg/cm3, respectively. Toxic exposure involves immunosuppressive, oxidative, hematoxic, and sensitizing effects and impaired hepatic etherifying function. With the higher toxicity of the compounds, the damaging action of monohydric alcohols on the organism increases and the spectrum of abnormal clinical and laboratory parameters expands.
构建疾病“环境决定因素”的证据基础是人类生态学和环境卫生领域的一个热门方向。一元脂肪醇在工业中的广泛应用,决定了有必要深入研究其对人体的毒性作用,同时要考虑到它们在血液中形成的实际浓度。研究结果得出结论,当血液中丁醇、丙醇和甲醇的浓度分别超过0.03、1.0 - 1.5和0.5微克/千克/立方厘米时,生物体接触一元醇的实际中毒风险就会形成。中毒接触涉及免疫抑制、氧化、血液毒性和致敏作用,以及肝脏醚化功能受损。随着这些化合物毒性的增加,一元醇对生物体的破坏作用增强,异常临床和实验室参数的范围也会扩大。