Lagoja Irene M
Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven.
Chem Biodivers. 2005 Jan;2(1):1-50. doi: 10.1002/cbdv.200490173.
This review describes the various manifestations of the pyrimidine system (alkylated, glycosylated, benzo-annelated.). These comprise pyrimidine nucleosides as well as alkaloids and antibiotics--some of them have been discovered and isolated from natural sources already long time ago, others have been reported very recently. A short overview on pyrimidine syntheses (prebiotic synthesis, biosynthesis, and metabolism) is given. The biological activities of most of the pyrimidine analogs are briefly described, and, in some cases, syntheses are formulated.
本综述描述了嘧啶系统的各种表现形式（烷基化、糖基化、苯并稠合的……）。这些包括嘧啶核苷以及生物碱和抗生素——其中一些早在很久以前就已从天然来源中发现和分离出来，其他的则是最近才报道的。本文还对嘧啶的合成（生命起源前合成、生物合成和代谢）进行了简要概述。简要描述了大多数嘧啶类似物的生物活性，在某些情况下还阐述了其合成方法。
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