Luzhetskyy Andriy, Vente Andreas, Bechthold Andreas
Pharmazeutische Biologie und Biotechnologie, Institut für Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität Freiburg im Breisgau, Stefan-Meier-Strasse 19, 79104 Freiburg, Germany.
Mol Biosyst. 2005 Jul;1(2):117-26. doi: 10.1039/b503215f. Epub 2005 Jun 23.
A unique characteristic of carbohydrates is their structural diversity which is greater than that of many other classes of biological compounds. Carbohydrate-containing natural products show many different biological activities and some of them have been developed as drugs for medical use. The biosynthesis of carbohydrate-containing natural products is catalysed by glycosyltransferases. In this review we will present information on the function of glycosyltransferases involved in the biosynthesis of oligosaccharide antibiotics focusing especially on urdamycins and landomycins, two angucycline antibiotics with interesting antitumor activities. We will also discuss the use of glycosyltransferases in combinatorial biosynthesis to generate new "hybrid" antibiotics.
碳水化合物的一个独特特征是其结构多样性，这种多样性比许多其他种类的生物化合物都要大。含碳水化合物的天然产物具有许多不同的生物活性，其中一些已被开发为医用药物。含碳水化合物天然产物的生物合成由糖基转移酶催化。在本综述中，我们将介绍参与寡糖抗生素生物合成的糖基转移酶的功能信息，尤其关注乌达霉素和地霉素，这两种具有有趣抗肿瘤活性的安古霉素类抗生素。我们还将讨论糖基转移酶在组合生物合成中用于生成新的“杂交”抗生素的应用。
