Lindor Noralane M, Smalley Regenia, Barker Melissa, Bigler Jeannette, Krumroy Lisa M, Lum-Jones Annette, Plummer Sarah J, Selander Teresa, Thomas Sushma, Youash Michelle, Seminara Daniela, Casey Graham, Bapat Bharati, Thibodeau Stephen N
Department of Medical Genetics, Mayo Clinic, Rochester, MN 55905, USA.
Cancer Biomark. 2006;2(1-2):5-9. doi: 10.3233/cbm-2006-21-202.
According to recently published guidelines, microsatellite instability (MSI) testing of colorectal cancers may be clinically indicated on a significant proportion of all colorectal tumors. To date, nothing has been published regarding the reproducibility of MSI testing between laboratories. We present MSI quality control activities experience of a six center multinational consortium, as laboratories developed competency with MSI testing and interpretation. The aim of this paper is to share lessons learned and to describe the final concordance rates in scoring MSI markers within this consortium.
根据最近发布的指南，在所有结直肠癌肿瘤中，相当大比例的病例可能需要进行结直肠癌微卫星不稳定性（MSI）检测。迄今为止，尚未有关于不同实验室间MSI检测可重复性的相关报道。随着各实验室在MSI检测及解读方面能力的提升，我们展示了一个六中心跨国联盟的MSI质量控制活动经验。本文旨在分享经验教训，并描述该联盟内MSI标记评分的最终一致性率。
