Inoue H, Yamashita T, Usui M, Nozaki A, Saihara S, Sugimoto T
Second Department of Internal Medicine, Tokyo University Hospital, Japan.
J Cardiovasc Pharmacol. 1991 Jul;18(1):137-43. doi: 10.1097/00005344-199107000-00018.
Effects of new antiarrhythmic drugs, pentisomide [3.5 +/- 0.5 mg/kg intravenously (i.v.) n = 8], and E-4031 (5.6 +/- 1.0 micrograms/kg, n = 8), a class III drug, on atrial flutter (AF) caused by reentry were compared with those of disopyramide (1.6 +/- 0.2 mg/kg, n = 8) and propafenone (2.2 +/- 0.2 mg/kg, n = 8). AF was induced with burst atrial pacing after we made an intercaval crush in anesthetized, open-chest dogs. Termination of AF did not differ among test drugs (8 of 8 with disopyramide, 7 of 8 with propafenone, 6 of 8 with pentisomide, and 8 of 8 with E-4031). Cycle length (CL) of AF was prolonged more with propafenone (57 +/- 10%) and pentisomide (41 +/- 5%) than with E-4031 (12 +/- 3%, p less than 0.05). This was also true for increase in interatrial conduction time determined at a pacing CL of 150 ms. Increase in atrial effective refractory period (ERP) determined at a basic pacing CL of 300 ms did not differ among test drugs. Changes in CL of AF correlated significantly with those in interatrial conduction time (r = 0.84, p less than 0.001), but not with those of ERP (r = 0.10, NS). Reinitiation of AF was significantly greater in propafenone (7 of 7) and pentisomide (5 of 6) groups than in disopyramide (1 of 8) and E-4031 (0 of 8) groups (p less than 0.001). Pentisomide and E-4031 were effective in terminating canine AF due to reentry, as were disopyramide and propafenone. Reinitiation of AF was greater in dogs treated with antiarrhythmic drugs that had more prominent effects on conduction time than on ERP.
将新型抗心律失常药物喷替索米（静脉注射剂量为3.5±0.5毫克/千克，n = 8）和Ⅲ类药物E - 4031（5.6±1.0微克/千克，n = 8）对折返引起的心房扑动（AF）的作用，与丙吡胺（1.6±0.2毫克/千克，n = 8）和普罗帕酮（2.2±0.2毫克/千克，n = 8）进行了比较。在麻醉开胸犬的腔静脉间进行挤压后，通过短阵心房起搏诱发AF。各受试药物终止AF的效果无差异（丙吡胺组8只中有8只、普罗帕酮组8只中有7只、喷替索米组8只中有6只、E - 4031组8只中有8只）。普罗帕酮（57±10%）和喷替索米（41±5%）使AF的周期长度（CL）延长的幅度大于E - 4031（12±3%，p＜0.05）。在起搏CL为150毫秒时测定的心房传导时间增加情况也是如此。在基础起搏CL为300毫秒时测定的心房有效不应期（ERP）增加情况在各受试药物间无差异。AF的CL变化与心房传导时间变化显著相关（r = 0.84，p＜0.001），但与ERP变化无关（r = 0.10，无统计学意义）。普罗帕酮组（7只中的7只）和喷替索米组（6只中的5只）AF再发的情况显著多于丙吡胺组（8只中的1只）和E - 4031组（8只中的0只）（p＜0.001）。喷替索米和E - 4031在终止犬折返性AF方面有效，丙吡胺和普罗帕酮也是如此。在接受对传导时间影响比对ERP影响更显著的抗心律失常药物治疗的犬中，AF再发情况更严重。
